Sulfobutyl ether-β-cyclodextrin is a cyclodextrin derivative with properties that enhance water solubility and bioavailability. It finds various applications in formulations, including but not limited to:

Enhancer for drug delivery: Sulfobutyl ether-β-cyclodextrin can be used as a component of drug delivery systems to improve the solubility of poorly water-soluble drugs, thereby enhancing their bioavailability and therapeutic effects.

Oral formulations: Sulfobutyl ether-β-cyclodextrin can be utilized in oral formulations such as oral solutions, capsules, or tablets to enhance drug solubility and oral absorption.

Ophthalmic formulations: In ophthalmic formulations like eye drops or eye ointments, sulfobutyl ether-β-cyclodextrin can serve as a solubilizing agent, aiding in the penetration of drugs into ocular tissues and improving bioavailability.

Topical formulations: Sulfobutyl ether-β-cyclodextrin can also be employed in topical formulations such as skin gels or creams to enhance drug solubility and local absorption properties.

Stabilizer: In certain cases, sulfobutyl ether-β-cyclodextrin can act as a stabilizer in formulations, helping to protect drugs from the effects of light, heat, or chemical reactions.

Overall, the application of sulfobutyl ether-β-cyclodextrin in formulations primarily leverages its solubilizing and stabilizing properties to enhance the solubility, absorption, and stability of drugs, thereby improving their therapeutic efficacy and safety.