The basic principle of cyclodextrin inclusion complexation involves several key points:

Cavity Structure: Cyclodextrins possess a molecular structure with one or more cavities capable of accommodating appropriately sized molecules. The size and shape of these cavities determine their ability to encapsulate specific molecules.

Molecular Encapsulation: When molecules of suitable size and shape enter the cavities of cyclodextrins, they form stable inclusion complexes with the cyclodextrin molecules. This is typically due to non-covalent interactions between the molecules, such as van der Waals forces, hydrogen bonding, etc.

Alteration of Physicochemical Properties: Once the inclusion complex is formed, the physicochemical properties of the encapsulated molecules are altered. For example, solubility may increase, stability may improve, and chemical reaction rates may be affected.

Applications: Cyclodextrin inclusion complexes are commonly used in drug delivery, enhancing drug stability, regulating drug release rates, etc. Additionally, they find wide applications in chemical separations, chemical analysis, and other fields.

In summary, the basic principle of cyclodextrin inclusion complexation utilizes the cavity structure of cyclodextrins and the interactions between molecules to encapsulate other molecules, thereby altering their physicochemical properties.