Platelet infusion and blood transfusion are the most common and effective means to treat uncontrolled bleeding. In recent years, artificial platelets constructed with carrier-supported peptides have become a new research direction for hemostatic materials.

Zhang Jiwen, a researcher at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, has invented a cube-like nanomaterial that can effectively stop bleeding. The material is composed of Gamma Cyclodextrin (CD) as a unit, and gamma cyclodextrin is a ring structure compound composed of 8 glucose units, which is a relatively safe pharmaceutical excipient. Cyclodextrin metal-organic framework (CD-MOF), with cyclodextrin as the organic ligand and potassium ion as the inorganic metal center, forms a novel drug carrier with high safety and regular cube morphology. The researchers synthesized a crosslinked CD-MOF (CL-MOF) based on a cube of CD-MOF that removes potassium ions. CL-MOF is a highly netted cubic nanoparticle composed of cyclodextrins. GRGDS was used to simulate the clotting mechanism of fibrinogen. After the functional modification of the particle surface, GS5-MOF was constructed.

This study is the first to use cubic nanomaterials with the raw material as a pharmaceutical excipient cyclodextrin for targeted therapy of uncontrolled bleeding. The cube GS5-MOF is not only an efficient hemostatic agent, but also a drug carrier that can be targeted to deliver therapeutic drugs. It has broad application prospects for the targeted diagnosis and treatment of vascular related diseases such as uncontrolled bleeding, atherosclerosis and stroke, and is expected to improve the therapeutic effect of thrombolytic drugs and reduce toxic side effects. It is a new drug delivery technology for vascular diseases.