Voriconazole is an antifungal drug used to treat various fungal infections, including Candida and Aspergillus infections. However, the solubility of voriconazole itself is relatively lower, which may limit its absorption and distribution in vivo, thereby reducing its bioavailability.

Betadex sulfobutyl ether sodium is a cyclodextrin derivative with the ability to form complex compounds with drug molecules. By adding betadex sulfobutyl ether sodium to the formulation of voriconazole, a betadex sulfobutyl ether sodium voriconazole containing complex can be formed. This complex enhances the solubility of voriconazole in water, thereby improving its oral absorption efficiency. It can better release and absorb voriconazole in the body, thereby enhancing its bioavailability and therapeutic effect.

The function of sodium sulfobutyl beta cyclodextrin in voriconazole is to act as a solubilizer, helping to overcome the solubility limitations of voriconazole drugs, enhancing the water solubility of voriconazole, promoting its absorption and bioavailability in vivo, and improving treatment efficacy.