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The dual role of hydroxypropyl betacyclodextrin in solubilizing and flavor masking of Enrofloxacin soluble powder

Enrofloxacin is a chemically synthesized third generation quinolone and a special fluoroquinolone for livestock and poultry. The technical difficulty of enrofloxacin soluble powder is to mask the bitter taste. In addition, the disintegrability of the preparation product in water is poor, it is not soluble in water, and it can only be fed with mixed materials, and it can not be used in drinking water on birds, causing inconvenience and drug waste, and threatening environmental safety.

In view of the above problems, the double masking technology of molecular inclusion and spray slow-release was used to achieve good masking effect, which solved the problem of limited clinical use of enrofloxacin bitter. The addition of hydroxypropyl beta cyclodextrin in enrofloxacin powder preparation can not only solve the problem of water solubility, but also achieve the purpose of masking the taste of the drug through slow release in the animal mouth, which can avoid the phenomenon of conventional coating and masking the taste of ordinary Enrofloxacin granule preparation, which has great technical advantages.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is a high-tech enterprise focusing on the research and development, production and application of cyclodextrin derivatives and cyclodextrin inclusions. It has a complete research and development, quality inspection center and professional scientific research team, and maintains long-term cooperative relations with Nankai University, Shandong University and Fudan University. It is a domestic production enterprise with many kinds and complete specifications of cyclodextrin. Welcome to call to consult related questions.

Leading Manufacture And Solution Provider Of Cyclodextrin Derivatives