Azelaic acid limited solubility in water and potential instability present challenges in cosmetic formulation. Hydroxypropyl betadex (HPβCD) can form inclusion complexes with hydrophobic molecules wih azelaic acid, Azelaic Acid/Cyclodextrin Complex advantages:

1. Cyclodextrins have a hydrophobic cavity in their structure, which can accommodate the hydrophobic moieties of azelaic acid, thereby enhancing its solubility in aqueous solutions. This increased solubility can lead to better bioavailability and efficacy in topical formulations。
2. Complexation with cyclodextrins can protect azelaic acid from degradation, particularly from factors such as light, heat, or oxidation. This can help maintain the stability of azelaic acid in formulations, prolonging its shelf-life and effectiveness.
3. Cyclodextrin complexes can improve the permeation of azelaic acid through the skin barrier. This can result in better delivery of the active ingredient to the target site, leading to improved therapeutic outcomes.
4. Complexation with cyclodextrins may also reduce skin irritation associated with azelaic acid, as it can help in modulating its release profile and minimizing direct contact with the skin.