Hydroxypropyl-gamma-cyclodextrin (HPγCD) is a modified cyclodextrin derivative. It is obtained by introducing hydroxypropyl groups onto the gamma-cyclodextrin molecule. Structurally, HPγCD is similar to hydroxypropyl-beta-cyclodextrin(HPβCD) and hydroxypropyl-alpha-cyclodextrin (HPαCD), but typically contains eight glucose units in its cyclic structure.And it can interact with larger molecules. It is a very useful chemical for Supramolecular chemistry.

Zhiyuan Biotech has passed ISO9001 quality system certification, ISO14001:2015 environmental management system certification, and ISO45001:2018 occupational health and safety management system certification.

The company has established a domestically advanced GMP standard clean production system for pharmaceutical excipients and a complete development and quality inspection center. Cyclodextrin reagents are domestically proprietary and are exclusively supplied to university laboratories and scientific research institutions at home and abroad.

Hydroxypropyl gamma cyclodextrin manufacturer-Shandong Binzhou Zhiyuan Biotechnology Co., Ltd which has completed registration with FDA, and the registration information is as follows:

Company name: Shandong Binzhou Zhiyuan Biotechnology Co., Ltd

FDA ESTABLISHMENT IDENTIFIER (FEI No.)：3011680310

ESTABLISHMENT ADDRESS: Boxing Economic Development Zone,, Binzhou, Shandong 256500, China (CHN)

DUNS: 548171477

Hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) exhibits increased water solubility compared to its parent compound, gamma-cyclodextrin. At 25°C, HP-γ-CD can reach a solubility of up to 80g/100ml in water. This enhanced solubility is attributed to the hydroxypropyl groups attached to the cyclodextrin molecule, which increase its hydrophilicity and improve its interaction with water molecules.

Furthermore, it’s important to note that HP-γ-CD is not a single pure compound but rather a mixture of multiple substituted compounds. The introduction of hydroxypropyl groups onto the gamma-cyclodextrin structure leads to the coexistence of various substitution patterns within the HP-γ-CD molecule. This structural diversity contributes to the versatility of HP-γ-CD and its ability to accommodate a wide range of guest molecules.

Due to the increased complexity and structural variations, HP-γ-CD exhibits unique properties compared to pure gamma-cyclodextrin. Specifically, the presence of multiple substitution sites and patterns makes it more challenging for HP-γ-CD to form inclusion crystallization with guest molecules. Inclusion crystallization refers to the formation of well-defined crystalline inclusion complexes where guest molecules are encapsulated within the cyclodextrin cavity. The reduced propensity for inclusion crystallization in HP-γ-CD can be attributed to the steric hindrance caused by the hydroxypropyl groups, hindering the perfect alignment required for crystallization.

Overall, HP-γ-CD demonstrates higher water solubility and stronger anti-crystallization ability compared to gamma-cyclodextrin. These characteristics make HP-γ-CD a valuable tool in various applications, such as solubilization, stabilization, taste masking, and controlled drug release, where improved water solubility and reduced crystallization tendencies are beneficial.

1. The quality is stable and has been audited by customers many times and received high praise.

2. Complete China CDE filing and U.S. FDA filing.

3. Binzhou Zhiyuan Biotechnology obtained ISO 9001, ISO14001, and ISO45001 certifications

4. Strong supply capacity: 100 tons/year

5. Provide technical support.

● Internal packing: packed PE bag, then put into aluminum foil bag

● Storage: Preserve well-closed containers protect from moisture.

● Label: according to customers’ request.

● Outer packing: packed in drum.

● Packing:100g/bag, 1kg/bag, 2kg/bag, 10kg/bag/drum, 20kg/bag/drum